The Helios Automated IFA System from Thermo Fisher Scientific automates processing and imaging on a single platform to enhance the diagnosis of autoimmune diseases. The FDA-cleared software identifies seven immunofluorescence patterns, including ANA HEp-2, c-ANCA, p-ANCA, and dsDNA (Crithidia luciliae). Scalable for laboratories of any size, Helios can process up to 190 bar coded samples, handle up to 20 slides, and utilize up to four different substrates per run. The system automates various aspects of the IFA diagnostic process, including dilution, incubation, washing, and pipetting mounting media before imaging. The system’s HTC module can maintain optimal internal temperature and humidity, helping to deliver precise and reliable results for healthcare providers and patients regardless of external environmental factors or location.