The AVENIO Edge System from Roche Diagnostics is a preanalytical platform for sequencing library preparation, target enrichment, and quantification steps that assists in delivering integrated, end-to-end control with reliable, consistent results. The system’s high reproducibility and low error rate can support the goal of reducing the number of rejected samples that otherwise might have to be recollected. Offering ready-to-use components in addition to customizable workflow parameters, the system aims to provide a scalable, cost-efficient solution for sequencing laboratories seeking performance and agility. Offering a quick setup time, this walkaway system has demonstrated a low error rate and a reduction in hands-on time.